Zepbound Dosing and Injection Instructions

Congratulations on your decision to begin your weight loss journey with Zepbound and our team at JourneyLite Physicians! Please review the information on this page for important information before you start your medication.

How to Inject Zepbound

Keep pen in refrigerator until ready for use. If this is not possible, pens can be left out for up to 21 days safely. Once a pen is left out, DO NOT put it back in the refrigerator. Leave the gray base cap on until you are ready to inject. Make sure the pen is locked. Do not unlock the pen until you place the clear base on your skin and are ready to inject. Pull the gray base cap straight off and throw it away in your household trash. Do not put the gray base cap back on – this could damage the needle. Do not touch the needle. Place the clear base flat against your skin at the injection site. Unlock by turning the lock ring. Press and hold the purple injection button for up to 10 seconds. Listen for:         –First click = injection started         –Second click = injection completed You will know your injection is complete when you can see the gray plunger. Dispose of the empty syringe in an FDA-approved sharps container or a heavy-duty household plastic container such as those used for detergent..

Common Side Effects:

The most common side effects of Zepbound (tirzepatide) include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or doesn’t go away.

Other Important Info:

• If you take birth control pills by mouth, talk to your healthcare provider before you use Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may recommend another type of birth control for 4 weeks after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.
• Use Zepbound 1 once a week. Stick to the same day of the week, and you can inject at any time of the day.
  • If you miss a dose of Zepbound and the next scheduled dose is more than 2 days away, take the missed dose as soon as possible.
  • If you miss a dose of Zepbound and the next scheduled dose is less than 2 days away, do not administer the dose. Take your next dose on the regularly scheduled day.
  • If you miss doses of Zepbound for more than 2 weeks, take the next dose on the regularly scheduled day or call your health care provider to talk about how to restart your treatment.
• Change (rotate) your injection area with each weekly injection. Do not use the same site for each injection.